Oxidative cyclization of alkenols with Oxone using a miniflow reactor

• Yoichi M. A. Yamada,
• Kaoru Torii and
• Yasuhiro Uozumi

Beilstein J. Org. Chem. 2009, 5, No. 18, doi:10.3762/bjoc.5.18

• within 5 or 10 min of residence time. Keywords: alkenols; cyclic ethers; miniflow reaction; oxidative cyclization; Oxone; Introduction The development of flow-reaction systems for molecular transformations is an important goal in organic syntheses. Recently, innovative devices such as micro- and

• carbinols with Oxone via a miniflow reaction system. Results and Discussion Furanyl and pyranyl carbinols have generated considerable interest due to their presence in a number of therapeutically and biologically active compounds [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. We therefore

• conventional batch system to a miniflow system. The miniflow reaction system is composed of poly(tetrafluoroethylene) (PTFE) tubes of ø = 1 mm, T-shaped connectors, and syringes with syringe pumps as shown in Figure 1. When the miniflow reaction of the alkenols 1 in i-PrOH with an aqueous solution of Oxone was